Grignard reactions of nonmetallic substances

Lithiations and Grignard Reactions on Pyrimidine and Quinazoline

Pyrimidine and quinazoline structural motifs are abundantly found in naturally occurring compounds, with uracil, thymine, and cytosine being the most prominent representatives. Furthermore, the pyrimidine core constitutes a subunit of many compounds rendering substantial medicinal or economic benefits. This review focuses on lithiations and Grignard reactions as tools for selective yet variable...

Reactions of Dyes with Cell Substances

Thionine is a metachromatic stain commonly used by histologists. In our preliminary survey of the staining of smears of purified nuclear materials (l), it was noted that thionine gave color variation but not reliable differentiation among the substances. The color variations were not conditioned by pH or by the acidity or basicity of the materials, as with hematoxylin. Thionine has been much us...

Genetics of Sensory Thresholds: Individual Taste Reactions for Different Substances.

Stereospecific Nickel-Catalyzed Cross-Coupling Reactions of Benzylic Ethers with Isotopically-Labeled Grignard Reagents

In this manuscript we highlight the potential of stereospecific nickel-catalyzed cross-coupling reactions for applications in the pharmaceutical industry. Using an inexpensive and sustainable nickel catalyst, we report a gram-scale Kumada cross-coupling reaction. Reactions are highly stereospecific and proceed with inversion at the benzylic position. We also expand the scope of our reaction to ...

Reactions of 6-aminopenicillanic acid with carbohydrates and related substances.